AI-Powered Antibody Engineering: Optimize and Humanize

AI-Powered Antibody Engineering: Optimize and Humanize

The AI-Powered Antibody Engineering skill streamlines the analysis of antibody sequences by numbering variable domains, annotating Complementarity-Determining Regions (CDRs), and evaluating developability from sequence data. It applies multiple numbering schemes such as IMGT, Kabat, Chothia, Martin, or AHo using ANARCI, and scans for chemical liabilities like N-glycosylation sequons, deamidation, and oxidation. It calculates physicochemical properties and assists in humanization planning through CDR grafting.

What this skill does

• Numbers antibody variable domains using schemes like IMGT, Kabat, Chothia, and others via ANARCI.
• Annotates CDRs and framework regions.
• Scans sequences for chemical liabilities such as N-glycosylation sequons, deamidation, isomerisation, oxidation, unpaired cysteine, and fragmentation.
• Calculates physicochemical properties including isolectric point (pI), net charge, extinction coefficient and hydrophobicity.
• Facilitates humanization through CDR grafting.

Who it is for

This AI skill is designed for developers and teams utilizing AI coding agents like Claude Code, Cursor, and Codex. It is particularly relevant for researchers and bioengineers working in the field of antibody development and optimization.

Use cases

• Sequence-level analysis of antibodies, nanobodies, and other variable-domain formats.
• Early-stage identification of chemical liabilities, minimizing potential issues before entering the modeling phase or wet-lab work.
• Planning and performing humanization of antibodies through precise CDR grafting techniques.

Technical details

This skill integrates with agent-plugins, aiapplication, and antibody-engineering tools. It leverages capabilities within AI coding platforms such as Claude Code, Cursor, and Codex. For detailed understanding, consult provided references on numbering schemes, developability, humanization, and related tools.

Source & Licence

This package is built on open-source work published by K-Dense-AI (K-Dense-AI/drug-discovery-agent-skills) and distributed under MIT. The original licence text and copyright notice are included in your download.

Personal and commercial use, modification and redistribution are permitted, provided the original copyright and licence notice are retained.

Your purchase covers curation, licence verification, packaging, documentation and instant delivery. It does not grant exclusive rights to the underlying open-source code, which remains available under its original licence.

Delivery & Support

• Delivery: instant — a secure download link is emailed to you as soon as payment is confirmed.
• Format: ZIP archive containing the skill files, documentation and the original licence.
• Support: support@mcpcart.com — we aim to reply within 2 business days.
• Updates: updates are included only where stated on this page.

Refunds

This is a digital product delivered immediately after purchase. By completing your order you request immediate delivery and acknowledge that, once the download has been accessed, the statutory right to cancel no longer applies to the extent permitted by law. Refund requests are handled in accordance with our published Refund Policy.

Claude, Codex, Gemini and Cursor are trademarks of their respective owners. MCP Cart is an independent marketplace and is not affiliated with, endorsed by, or sponsored by any of them. Compatibility references describe interoperability only.